13C NMR (101 MHz, DMSO-= 8.9 Hz, 2H), 7.55 (d, = 8.9 Hz, 2H), 7.48 (dd, = 14.3, 7.7 Hz, 2H), 7.23 (td, = 7.7, 1.0 Hz, 1H), 7.15 (td, = 7.8, 1.2 Hz, 1H). acetate (80/20) at a circulation rate of 0.3 mL/min. All reactions carried out under microwave irradiation were performed with the CEM Discover SP microwave synthesizer, using the dynamic mode in the following settings: maximum amount of microwave power (150 W), premixing time (1 min), and stirring rate (high). A simultaneous chilling of the reaction vessel provided by compressed air flow (24 psi) was applied during the entire experiment (PowerMax option ON). All 0.5 mmol level reactions were performed inside a 10 mL borosilicate glass reaction vessel closed having a disposable silicon cap and equipped with a Teflon-coated egg-shaped magnetic stir bar. The heat was monitored by an external infrared sensor. General Methods and Characterization of Individual Compounds Cyclization of Aminophenols with NCTS = 7.8 Hz, 1H), 7.19 (d, = 7.3 Hz, 1H), 7.08 (t, = 7.2 Hz, 1H), 6.95 (t, = 7.2 Hz, 1H). 13C NMR (101 MHz, DMSO-= 8.0 Hz, 1H), 7.00 (s, 1H), 6.75 (d, = 7.9 Hz, 1H), 2.30 (s, 3H). 13C NMR (101 MHz, DMSO-= 7.9 Hz, 1H), 6.90 (d, = 7.6 Hz, 1H), 2.32 (s, 3H). 13C NMR (101 MHz, DMSO-= 8.7 Hz, 1H). 13C NMR (101 MHz, DMSO-= 8.7, 2.3 Hz, 1H), 7.32 (d, = 8.7 Hz, 1H). 13C NMR Quetiapine fumarate (101 MHz, DMSO-= 8.4 Hz, 1H), Quetiapine fumarate 7.22 (d, = 2.1 Hz, 1H), 6.97 (dd, = 8.4, 2.2 Hz, 1H). 13C NMR (101 MHz, DMSO-= 1.8 Hz, 1H), 7.17 (d, = 8.3 Hz, 1H), 7.12 (dd, = 8.3, 2.0 Hz, 1H). 13C NMR (101 MHz, DMSO-= 1.7 Hz, 1H), 7.65 (dd, = 8.3, 1.7 Hz, 1H), 7.63 (s, 2H), 7.43 (d, = 8.3 Hz, 1H), 3.84 (s, 3H). 13C NMR (101 MHz, DMSO-= 8.3 Hz, 2H), 7.30 (d, = 8.2 Hz, 2H), 7.13 (dd, = 8.0, 1.6 Hz, 1H), 6.91 (td, = 7.9, 1.6 Hz, 1H), 6.72 (dd, = 8.0, 1.1 Hz, 1H), 6.68 (td, = 7.9, 1.4 Hz, 1H), 2.33 (s, 3H). 13C NMR (101 MHz, DMSO-= 5.6 Hz, 1H), 7.32 (d, = 7.8 Hz, 1H), 7.23 (d, = 7.1 Hz, 1H), 7.10 (td, = 7.6, 1.0 Hz, 1H), 6.96 (td, = 7.7, 1.2 Hz, 1H), 3.39 (dd, = 12.6, 6.7 Hz, 2H), 2.56 (dd, = 13.8, 6.8 Hz, 2H), 2.40 (t, = 7.3 Hz, 1H), 1.86 (p, = 6.9 Hz, 2H). 13C NMR (126 MHz, DMSO-= 5.6 Hz, 2H), 7.31 (d, = 7.8 Hz, 2H), 7.23 (d, = 7.4 Hz, 2H), 7.09 (td, = 7.7, 0.9 Hz, 2H), 6.96 (td, = 7.8, 1.1 Hz, 2H), 3.39 (dd, = 12.7, 6.6 Hz, 4H), 2.81 (t, = 7.1 Hz, 4H), 2.03C1.90 (m, 4H). 13C NMR (126 MHz, DMSO-= 5.7 Hz, 2H), 7.33 (d, = 7.8 Hz, 2H), 7.25 (d, = 7.6 Hz, 2H), 7.10 (td, = 7.5, 0.9 Hz, 2H), 6.97 (td, = 7.7, 1.1 Hz, 2H), 3.61 (dd, = 12.9, 6.4 Hz, 4H), 3.01 (t, = 6.7 Hz, 4H). 13C NMR (101 MHz, DMSO-= 7.9, 0.5 Hz, 1H), 7.25 (dd, = 7.8, 0.8 Hz, 1H), 7.12 (td, = 7.7, 1.1 Hz, 1H), 6.97 (td, = Quetiapine fumarate 7.7, 1.3 Hz, 1H), 3.54 (ddd, = 6.7, 4.3, 2.6 Hz, 4H), 2.00C1.93 (m, 4H). 13C NMR (101 MHz, DMSO-= 6.5 Hz, 2H), 1.85C1.71 (m, 2H), 1.53C1.35 (m, 4H). 13C NMR (101 MHz, DMSO-= 6.3 Hz, 2H), 1.84C1.73 (m, 2H), 1.50C1.38 (m, 4H). 13C NMR (101 MHz, DMSO-= 6.1 Hz, 1H), 7.56C7.49 (m, 2H), 7.34 (d, = 8.6 Hz, 3H), 7.24 (dd, = Rabbit Polyclonal to TRMT11 7.8, 0.6 Hz, 1H), 7.10 (td, = 7.6, 1.0 Hz, 1H), 6.98 (td, = 7.7, 1.2 Hz, 1H), 4.50 (d, = 6.0 Hz, 2H). 13C NMR (101 MHz, DMSO-= 7.0, 3.1, 1.2 Hz, 2H), 7.39C7.27 (m, 3H), 4.12 (s, 2H). 13C NMR (101 MHz, DMSO-= 7.7 Hz, 1H), 6.66 (t, = 1.9 Hz, 1H), 6.59 (d, = 7.5 Hz, 1H), 6.47 (m, 1H), 5.13 (br s, 2H), 4.47 (s, 2H). 13C NMR (101 MHz, DMSO-= 6.1 Hz, 1H), 7.41C7.30 (m, 5H), 7.25 (dd, = 15.1, 7.8 Hz, 2H), 7.10 (td, = 7.7, 1.0 Hz, 1H), 6.98 (td, = 7.8, 1.2 Hz, 1H), 4.52 (d, =.