Ubiquitin E3 Ligases

Ubiquitin E3 Ligases

While nuclear factor-kappa B (NF-B) and hypoxia-inducible factor 1-alpha (HIF-1) play essential roles in the growth and survival of hematopoietic malignancies13C15, VC inhibits the survival and growth of K562 leukemic cells via the downregulation of HIF-1 transcription by inhibiting NF-B activation and suppressing the expression of HIF-1-regulated antiapoptotic proteins of the Bcl-2 family, including myeloid leukemia cell differentiation protein (Mcl-1), B-cell lymphoma (Bcl)-xL, and Bcl-212

While nuclear factor-kappa B (NF-B) and hypoxia-inducible factor 1-alpha (HIF-1) play essential roles in the growth and survival of hematopoietic malignancies13C15, VC inhibits the survival

Ubiquitin E3 Ligases

(C21H22N2O4S) C, H, N

(C21H22N2O4S) C, H, N. (4-Amino-2-(4-tert-butylphenyl)thiazol-5-yl)(3,4,5-trimethoxyphenyl)methanone (3h) Following the general procedure, the crude residue, purified by flash chromatography using ethyl acetate/petroleum ether 4:6 (v/v) as eluent,