Finally, the results provide a structural framework to rationalize the mode of neutralization of antibodies targeting the conserved fusion machinery. Results Protease-Mediated Fusion Activation of

Substance 2p was ready following general treatment GP-A from azirine 1e (150 mg, 0.91 mmol), 4-bromobenzonitrile (14 g, 77 mmol) and Rh2(oct)4 (7 mg, 0.0091

Hence, there is an urgent need for engineering new antimalarial compounds having novel mechanisms of action. Ten plasmepsins (PMs) have been reported from the genome